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BOF: 224

A 24-year-old female presents with a history of passing large volumes of urine and excessive thirst. Clinical examination is unremarkable. The specific gravity of her urine is 1.003 and urine osmolality is 140 mOsm/L

In this patient you arrange a water deprivation test.

In the interpretation of the water deprivation test which of the following statements is true?

a)      A normal response is characterised by the maximum urine osmolality reaching the plasma osmolality

b)      In a normal response following injection of vasopressin the urine osmolality increases by > 50%

c)      Patients with nephrogenic diabetes insipidus do not concentrate their urine but show a marked response to vasopressin injection

d)      Patients with diabetes insipidus are unable to concentrate their urine and the response to vasopressin injection is an increase in concentration by 5 %

e)      Patient s with partial diabetes insipidus are able to concentrate their urine but show a response to vasopressin injection of > 9%

 

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