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 Best of Five 3.4

 

   

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BOF:3.4

A 38-year-old male presented initially with impaired vision of 6 hours duration. He had been bumping into objects, had been unable to see complete faces and had difficulty reading. No history of headache, neck pain or trauma. He gave a history of attacks of migraine with aura and had sensorineural deafness. His mother aged 65 has non-insulin dependent diabetes mellitus and his father has ischaemic heart disease. He was not homosexual.

On examination the positive findings were he was shorter than average, had sensorineural deafness and had a left homonymous hemianopia. There was no abnormality on examination of the cardiovascular system. No other positive findings.

Investigations showed normal haematology and biochemistry, coagulation screen was normal, ECG, transthoracic echocardiogram, chest x-ray were normal. CT scan of his head showed low-density changes in the right parieto-occipital region.

His hemianopia resolved within 72 hours, he was treated with aspirin and discharged.

8 months later he was re-admitted with a right-sided weakness and right homonymous hemianopia. MRI showed ischaemic changes in the both parieto-occipital regions and ischaemic changes in the left tempero-parietal region.

Which of the following would confirm your diagnosis:

a)      Transoesophageal echocardiography

b)      Homocysteine levels in blood

c)      Visual evoked potentials

d)      Lumbar puncture

e)      Muscle biopsy

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