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 BOF 183

 

   

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BOF 183
Osteomalacia and rickets, all are true, except:
1-due to aluminium toxicity, requires bone biopsy for diagnosis and may respond to desferrioxamine
2-due to hypophosphatasia, is very resistant to treatment due to pyrophosphate accumulation which inhibits bone mineralization
3-hypophosphatemic rickets respond well to life long phosphate replacement + vitamin D metabolites
4-type II vitamin dependent rickets responds favourably to active vitamin D metabolites
5-biphosphanate induced osteomalacia is usually transient and asymptomatic and seen mainly in Pagetís disease given high doses of etidronate



 

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