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 BOF 186

 

   

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BOF 186
In SLE, all are true: except:
1-there is monoclonal B and T cell activation
2-none of the diverse clinical manifestations of SLE can be attributed to a single antigenic stimulus
3-exacerbations can be induced by sun light, infection and pregnancy
4-the anti dsDNA antibodies although highly diagnostic but seen only in 30-50 of active disease patients
5-the renal lesions are due to immune complex disease while the brain damaging effect is mainly due to the antibody mediated cell cytotoxicity

 

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